DC Field | Value | Language |
dc.contributor.author | Aka, H. | - |
dc.contributor.author | Kksayan, H. | - |
dc.date.accessioned | 2018-05-04T07:35:41Z | - |
dc.date.available | 2018-05-04T07:35:41Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Akзa, H. MiR-520e can regulate Transforming growth Factor signaling and inhibit NSCLC invasion / H. Akзa, H. Kьзьksayan // BIG DATA Advanced Analytics: collection of materials of the fourth international scientific and practical conference, Minsk, Belarus, May 3 – 4, 2018 / editorial board: М. Batura [etc.]. – Minsk, BSUIR, 2018. – Р. 98 – 97. | ru_RU |
dc.identifier.uri | https://libeldoc.bsuir.by/handle/123456789/31343 | - |
dc.description.abstract | Transforming growth factor-β (TGF-β) pathway plays crucial roles during the carcinogenesis and metastasis. Transforming growth factor-β receptor 2 (TGFBR2) is a key molecule
for the regulation of TGF-β pathway and frequently downregulated or lost in several cancer types
including non-small cell lung cancer (NSCLC). However, little is known about the mechanism of
miRNA-mediated TGFBR2 downregulation in NSCLC. Also, TGF-β pathway is often regulated by
negative feedback mechanisms, which allow cancer cells to escape growth inhibition from TGF-β.
Here, we found that the significance of mir-520e for TGFBR2 downregulation and the negative regulation of TGF-β signaling in NSCLC. We demonstrate that mir-520e is upregulated in metastatic
tumor tissues compared to non-metastatic ones and its expression is inversely correlated with that of
TGFBR2 in clinical samples. We further discovered that TGF-β decreased TGFBR2 expression and,
treatments of the chemical inhibitors of histone deacetylase and DNA methyltransferase did not influence TGF-β-induced TGFBR2 downregulation. TGF-β dramatically increased the expression of
mir-520e targeting TGFBR2. ChIP-PCR experiments showed that mir-520e is transcriptionally induced by SMAD2/3 in response to TGF-β. Our findings reveal a novel negative feedback mechanism
in TGF-β signaling via mir-520e and that mir-520e overexpression could be a predictive factor for
NSCLC metastasis. This Work was financialy supported by TUBITAK ( Project code 215Z283). | ru_RU |
dc.language.iso | en | ru_RU |
dc.publisher | БГУИР | ru_RU |
dc.subject | материалы конференций | ru_RU |
dc.subject | miR-520e | ru_RU |
dc.subject | factor-β | ru_RU |
dc.subject | NSCLC | ru_RU |
dc.title | MiR-520e can regulate Transforming growth Factor signaling and inhibit NSCLC invasion | ru_RU |
dc.type | Статья | ru_RU |
Appears in Collections: | BIG DATA and Advanced Analytics. Использование BIG DATA для оптимизации бизнеса и информационных технологий (2018)
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